Show simple item record

dc.contributor.author Fard, Roxana en
dc.date.accessioned 2011-01-12T20:51:58Z en
dc.date.available 2011-01-12T20:51:58Z en
dc.date.issued 2010-09-25 en
dc.identifier.uri http://hdl.handle.net/10139/3015 en
dc.description.abstract Bone graft substitutes are commonly used as an alloplastic source for complex bone repair. Human mesenchymal stem cells (hMSCs) have become an idealistic source for bone repair and regeneration due to their potential to differentiate into osteogenic precursors. The purpose of engineering synthetic bone grafts it to successfully find a substitute that is biocompatible, bioresorbable, and has osteoconductive characteristics. The purpose of this study is to construct a bone biocomposite with an optimal amount of biphasic hydroxyapatite/β-tricalcium phosphate (HA-TCP) powder to promote hMSC proliferation with sufficient mechanical stiffness. Results have indicated an increase in metabolic proliferation over a 2-week time period. The constructs seeded with hMSCs exhibited a 3 to 9 fold or greater increase in proliferation depending on the formulation of the construct. This work demonstrates that higher volumes of HA-TCP promote hMSC proliferation in the constructs while maintaining sufficient mechanical stiffness. Optimizing the components of the scaffolds will allow for the most innovative biomimetic bone composite for mesenchymal stem cell differentiation into osteoblasts in an in vivo model. en
dc.language.iso en_US en
dc.rights All rights reserved to author and California State University Channel Islands en
dc.subject Biotechnology & Bioinformatics thesis en
dc.subject Ceramic scaffolds en
dc.subject Mesenchymal stem cells en
dc.subject Fibrin constructs en
dc.subject HA-TCP en
dc.title Optimization of Hydroxyapatite β-Tricalcium Phosphate – Fibrin Constructs for Human Mesenchymal Stem Cell Proliferation and Mechanical Strength en
dc.type Thesis en

Files in this item


This item appears in the following Collection(s)

Show simple item record

Search DSpace

My Account

RSS Feeds